Ceramide: a contributor to insulin resistance or an innocent bystander?
نویسندگان
چکیده
منابع مشابه
Resistin - a mediator of obesity-associated insulin resistance or an innocent bystander?
The objective of this review is to summarize the current evidence of a novel adipocytokine, resistin. Resistin is a novel peptide hormone that belongs to a family of tIssue-specific resistin-like molecules originally named for its resistance to insulin. Although a seminal proposal by Steppan et al. suggested resistin to be a hormone that links obesity to diabetes, several studies have subsequen...
متن کاملInsulin and atherosclerosis: villain, accomplice, or innocent bystander?
Initial descriptions of an association between insuli-naemia and both atherosclerotic cardiovascular disease and its risk factors appeared nearly 30 years ago. In 1969, Stout and Vallance-Owen suggested a direct role for insulin in atherogenesis.' Stout recently summarised laboratory studies supporting a direct atherogenic effect of insulin through stimulation of vascular smooth muscle prolifer...
متن کاملAlbumin: innocent bystander or culprit?
ALPORT SYNDROME (AS) is a hereditary glomerulopathy associated with hearing loss and ocular abnormalities that, if left untreated, inevitably progresses to glomerulosclerosis and endstage renal disease (ESRD) (6). AS is caused by mutations in collagen type IV genes and is associated with thickening and splitting of the glomerular basement membrane (GBM), ultimately rendering it leaky for albumi...
متن کاملInnocent Bystander or the Heel of Achilles.
Case Presentation A 29-year-old male presented with palpitations without a documented tachycardia. ECG showed minimal preexcitation (Figure 1A), and echo confirmed a normal heart. At electrophysiological study in the drug-free state, the HV interval was 13 ms in sinus rhythm, and ventricular (V) activation in the right paraHisian region preceded the surface delta wave (Figure 2A). Programmed st...
متن کاملHomocysteine--an innocent bystander in vascular disease?
Homocysteine is derived from the metabolism of methionine, an essential amino acid primarily found in dietary animal protein. Homocysteine concentrations are determined by genetic and nutritional factors; mutations in the genes for enzymes involved in homocysteine metabolism, such as the common 5,10-methylenetetrahydrofolate reductase (MTHFR) 677C T mutation, and deficiencies of vitamins B6, B1...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Diabetologia
سال: 2008
ISSN: 0012-186X,1432-0428
DOI: 10.1007/s00125-008-1015-y